New preclinical outcomes help the anti-fibrotic potential of engineered macrophages in a number of fibrosis fashions
Engineered TIM4-expressing macrophages appropriate faulty efferocytosis in MASH, demonstrating potent anti-fibrotic exercise
Liver fibrosis is a central late-stage pathway in a number of liver ailments, together with MASH, acute liver damage, major sclerosing cholangitis, major biliary cholangitis, and others. Remedy choices stay restricted for superior liver illness sufferers. Liver illness is characterised by faulty efferocytosis (an anti-inflammatory course of by which macrophages clear useless hepatocytes), activation of hepatic stellate cells which ends up in collagen accumulation, and power irritation.
New preclinical outcomes show that macrophages may be genetically engineered to focus on particular key pathways underlying liver illness with elements together with TIM4 (restores efferocytosis), relaxin (inhibits hepatic stellate cell activation), and IL10 (reduces irritation). Notably, a single dose of macrophages expressing TIM4, alone or along with relaxin, considerably lowered liver fibrosis and hepatic stellate cell activation within the translationally related choline-deficient, L-amino acid-defined, high-fat food regimen (CDAHFD) MASH mannequin. The engineered macrophages had been properly tolerated and outperformed non-engineered cells in all fashions.
“We are pleased to present compelling preclinical data supporting the therapeutic potential of our engineered macrophages to address a critical unmet need in liver fibrosis, which is found in advanced stages of MASH,” mentioned
Carisma expects to appoint a improvement candidate for its liver fibrosis program within the first quarter of 2025.
The poster introduced at AASLD 2024 is now obtainable on-line within the “Publications” part of Carisma’s web site at https://carismatx.com/know-how/publications/
About Carisma Therapeutics
Carisma Therapeutics Inc. is a clinical-stage biopharmaceutical firm targeted on using our proprietary macrophage and monocyte cell engineering platform to develop transformative immunotherapies to deal with most cancers and different critical ailments. Now we have created a complete, differentiated proprietary cell remedy platform targeted on engineered macrophages and monocytes, cells that play an important function in each the innate and adaptive immune response. Carisma is headquartered in
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