BURLINGAME, Calif., Nov. 09, 2024 (GLOBE NEWSWIRE) — Corvus Prescribed drugs, Inc. (NASDAQ: NASDAQ:), a clinical-stage biopharmaceutical firm, immediately introduced new information highlighting the potential of ciforadenant, the Firm’s adenosine A2A receptor antagonist, to beat resistance to anti-PD1 immunotherapy within the remedy of metastatic castration resistant prostate most cancers (mCRPC).
The information have been introduced immediately in an oral session on the Society for Immunotherapy of Most cancers (SITC) thirty ninth Annual Assembly by Aram Lyu, Ph.D., a postdoctoral fellow at Fred Hutch Most cancers Heart, College of California, San Francisco and Parker Scholar on the Parker Institute for Most cancers Immunotherapy. Dr. Lyu’s summary, titled Identification and therapeutic goal of myeloid-mediated mechanisms of immunotherapy resistance in prostate most cancers was chosen as a High 100 summary by SITC.
These research reveal vital particulars on the position of the adenosine pathway on the immunobiology of mCRPC, together with the significance of myeloid cells and the adenosine gene signature, stated Richard A. Miller, M.D., co-founder, president and chief govt officer of Corvus. The mechanism is according to and builds on outcomes from our medical trials in renal cell most cancers and prostate most cancers, together with the potential for the adenosine gene signature to pick out sufferers more than likely to reply. This may very well be an vital development for sufferers with tumors which are immune to checkpoint inhibitors, and is supportive of our ongoing medical trial of ciforadenant together with ipilimumab and nivolumab in entrance line renal cell most cancers.
SITC Oral Presentation Overview and Key Information
Earlier research have proven that mCRPC is immune to remedy with immune checkpoint inhibitors. Whereas tumor related macrophages are identified to contribute to immunosuppression with the tumor microenvironment, this examine recognized SPP1+ myeloid cells as a possible crucial mediator of resistance to immunotherapy. The crew led by Lawrence Fong, M.D. used single cell RNA expression profiling of tumor biopsies to measure ranges of those cells in sufferers with early localized or metastatic hormone responsive prostate most cancers in comparison with sufferers with mCRPC. The outcomes confirmed that SPP1+ macrophages have been extra prevalent as most cancers progresses to mCRPC sufferers.
Dr. Fong is the scientific director of the Immunotherapy Built-in Analysis Heart at Fred Hutch, the place he’s additionally a professor within the Translational Sciences and Therapeutics Division and a Bezos Household Distinguished Scholar in Immunotherapy.
The researchers created a murine mannequin that confirmed that SPP1+ macrophages have been related to suppressed immunity to prostate most cancers and shortened total survival. Additional evaluation of the associated genetic pathways revealed involvement of adenosine signaling by the adenosine 2A receptor. The researchers utilized ciforadenant to inhibit adenosine signaling on this mannequin and the important thing findings demonstrating its potential to beat this resistance to immunotherapy embrace:
- Ciforadenant remedy related to diminished immunosuppression and enhanced sensitivity to anti-PD1 remedy within the mannequin
- Ciforadenant remedy related to diminished SPP1+ macrophage infiltration within the tumors, supporting a shift to a much less immunosuppressive myeloid surroundings
- The Adenosine Gene Signature, a biomarker that displays adenosine induced immunosuppression within the tumor, was elevated in SPP1+ macrophages
- Outcomes from the mannequin have been according to information from the Part 1b/2 medical trial of ciforadenant in sufferers with mCRPC, which included information from 35 sufferers with superior mCRPC, together with 11 who obtained ciforadenant as a monotherapy (100 mg twice each day) and 24 that obtained ciforadenant (100 mg twice each day) together with atezolizumab (840 mg delivered intravenously each two weeks). 5 of 24 (21%) receiving mixture remedy had PSA partial responses outlined as PSA reductions >30%, in comparison with 1 of 11 (9%) receiving monotherapy
About Corvus Prescribed drugs
Corvus Prescribed drugs is a clinical-stage biopharmaceutical firm pioneering the event of ITK inhibition as a brand new method to immunotherapy for a broad vary of most cancers and immune illnesses. The Firm’s lead product candidate is soquelitinib, an investigational, oral, small molecule drug that selectively inhibits ITK. Its different clinical-stage candidates are being developed for quite a lot of most cancers indications. For extra data, go to www.corvuspharma.com.
About Ciforadenant
Ciforadenant (CPI-444) is an investigational small molecule, oral, checkpoint inhibitor designed to disable a tumor’s skill to subvert assault by the immune system by blocking the binding of adenosine to immune cells current within the tumor microenvironment. Adenosine, a metabolite of ATP (adenosine tri-phosphate), is produced throughout the tumor microenvironment the place it could bind to the adenosine A2a receptor current on immune cells and block their exercise. Ciforadenant has been proven to dam the immunosuppressive results of myeloid cells current in tumors and preclinical research printed in 2018 demonstrated synergy with mixtures of anti PD1 and anti-CTLA4 antibodies.
Adenosine Gene Signature
The adenosine gene signature is a biomarker that displays adenosine induced immunosuppression within the tumor. These genes specific chemokines that recruit myeloid cells together with immunosuppressive tumor related myeloid cells, that are thought to mediate resistance to anti-PD-(L)1 remedy.
Ahead-Wanting Statements
This press launch accommodates forward-looking statements, together with statements associated to the potential efficacy of the Firm’s product candidates together with ciforadenant; the potential use of ciforadenant to deal with metastatic renal cell most cancers and mCRPC, together with the potential to beat resistance to immunotherapy; and the potential for the adenosine gene signature to pick out sufferers more than likely to answer remedy. All statements aside from statements of historic reality contained on this press launch are forward-looking statements. These statements usually embrace phrases resembling imagine, count on, anticipate, intend, plan, estimate, search, will, might or comparable expressions. Ahead-looking statements are topic to numerous dangers and uncertainties, a lot of which contain components or circumstances which are past the Firm’s management. The Firm’s precise outcomes may differ materially from these acknowledged or implied in forward-looking statements because of numerous components, together with however not restricted to dangers detailed within the Firm’s Quarterly Report on Type 10-Q for the three months ended June 30, 2024, filed with the Securities and Alternate Fee on August 6, 2024, in addition to different paperwork which may be filed by the Firm once in a while with the Securities and Alternate Fee. Particularly, the next components, amongst others, may trigger outcomes to vary materially from these expressed or implied by such forward-looking statements: the Firm’s skill to show enough proof of efficacy and security in its medical trials of its product candidates; the accuracy of the Firm’s estimates regarding its skill to provoke and/or full preclinical research and medical trials and launch information from such research and medical trials; the outcomes of preclinical research and interim information from medical trials not being predictive of future outcomes; the Firm’s skill to enroll enough numbers of sufferers in its medical trials; the unpredictability of the regulatory course of; regulatory developments in the US and different international nations; the prices of medical trials might exceed expectations; and the Firm’s skill to lift further capital. Though the Firm believes that the expectations mirrored within the forward-looking statements are cheap, it can’t assure that the occasions and circumstances mirrored within the forward-looking statements might be achieved or happen, and the timing of occasions and circumstances and precise outcomes may differ materially from these projected within the forward-looking statements. Accordingly, you shouldn’t place undue reliance on these forward-looking statements. All such statements converse solely as of the date made, and the Firm undertakes no obligation to replace or revise publicly any forward-looking statements, whether or not because of new data, future occasions or in any other case.
INVESTOR CONTACT:
Leiv Lea
Chief Monetary Officer
Corvus Prescribed drugs, Inc.
+1-650-900-4522
llea@corvuspharma.com
MEDIA CONTACT:
Sheryl Seapy
Actual Chemistry
+1-949-903-4750
sseapy@realchemistry.com
Supply: Corvus Prescribed drugs, Inc.
